When I go to Wilmington, I take US 421 from Greensboro. That adds about 20 minutes, but bypasses that I 40/I 85 stretch. I do take 40 back at night.
Greensboro to Wilmington - Rural (Future I 695)
I haven't done I 73/US 74 though it looks to take the same amount of time as going 421. Going to...